"The ceasefire no longer exists," Grybauskaitė said in an interview to Reuters news agency.
"The situation is changing of course every day, but we are relying on NATO information, and NATO information is such that, really, the Minsk agreement is over," she said in an interview in the Lithuanian capital Vilnius.
Russian-supported separatists and the Ukrainian administration signed a ceasefire deal in the Belarusian capital Minsk on 12 February. However, the clashes did not fully stop.
Kiev and Western powers accuse Moscow of sending munitions and troops to help the separatists.
Russia has denied the accusations, saying that the Western world last year organized the overthrow of Ukraine's pro-Russian president.
More than 6,000 people have been killed in the conflict in Eastern Ukraine so far.
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